高教深耕計畫－107年中山高醫計畫：中山溫志宏教授＆高醫陳炳宏副教授「海綿化合物對於多型性膠質母細胞瘤之抑制作用」
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活動名稱 |
海綿化合物對於多型性膠質母細胞瘤之抑制作用 |
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活動時間 |
107年1月1日至12月31日 |
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活動地點 |
中山＆高醫 |
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參與對象 |
中山溫志宏教授＆高醫陳炳宏副教授 |
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參與人數 |
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活動目標 |
Glioblastoma multiforme (GBM) is the most aggressive brain cancer type which has high level of cell invasion, and angiogenesis. The survival ratio of GBM patients is less than 15 months, although treat with traditional surgical, radiotherapy, and chemotherapy. Compound A is a marine sponge -derived compound, exhibits unclear anti-cancer mechanism. Here, we investigated the cell survival inhibition of compound A in GBM cells. Moreover, we also found Compound A down-regulates Akt signaling pathway, which is important for migration and survival, in GBM cells. And decrease migration by Transwell invasion assay and scratch assay in GBM cells. Furthermore, Compound A locks the major proangiogenic factor VEGF expression and secretion in GBM cells. Therefore, we think Compound A is a potential agent that worthy to development on tumor therapy for anti-angiogenesis and anti-invasion ability in GBM.
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成果亮點 |
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後續規畫 |
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活動開始日期:
2018-01-01
活動結束日期:
2018-12-31
計畫類別:
高教深耕計畫-107年度中山高醫計畫
公告單位:
研發處
107年中山高醫期末海報格式(溫志宏陳炳宏).pdf
107年中山高醫期末成果報告表(溫志宏陳炳宏).docx
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